Answer TWO questions (ONE QUESTION FROM EACH SECTION), each on a separate exam answer document template.
SECTION A:
Answer ONE question (on a separate exam answer document template)
1.Genetic mutations in the nesprin-2 gene are very common in breast cancers. The majority of genetic defects constitute missense mutations that affect conserved residues within the five C-terminal spectrin repeats (SR52-56 for Nesprin-2 giant). Provide plausible molecular and cellular mechanisms that involve nesprins in the pathogenesis of breast cancer. Justify your answer and within your answer suggest:
• Experiments that will allow you to evaluate potential pathomechanisms that underpin metastasis.
• Therapeutic strategies that are based on targeting nesprin biology in breast cancer.
2.Discuss the functional significance of the enormous isoform diversification of KASH-domain proteins in cell architecture, health and disease.
SECTION B:
Answer ONE question (on a separate exam answer document template)
3.“Form follows function” (Louis Sullivan, 1896). Discuss this statement with respect to the nuclear transport system.
4.Discuss the experimental evidence that supports different models for the molecular mechanisms of translocation through the nuclear pore complex and comment on which model is likely to be the correct.
5.Describe TWO models for how cells decide where they will divide, and experimental evidence that support them. Propose a different experimental approach that could test these models.
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